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Ambien (Zolpidem) is a prescription medication used for short term treatment of insomnia. It belongs to a group of drugs called sedative-hypnotics that work by depressing the central nervous system and slowing down brain activity? While Ambien is generally considered safer than certain other sedatives, it can still be misused. Long-term use may lead to tolerance, dependence, and withdrawal.
When used as prescribed, the traditional form of the drug is taken at bedtime to help users fall asleep. The extended-release version hit the market in 2005 with two layers - the first to put you to sleep and the second, internal layer helped to keep you that way. According to Forbes Magazine, US physicians doled out 40 million prescriptions for the sedative hypnotic drug in 2011.
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Inside (immediately before bed) in a single dose of 10 mg. In elderly or debilitated patients, if liver function is impaired, treatment is started with a dose of 5 mg. If necessary (insufficient clinical effect) and good tolerability of the drug, the dose may be increased to 10 mg. The maximum daily dose is 10 mg. The course of treatment should not exceed 4 weeks. With transient insomnia, the recommended course of treatment is 2-5 days, in case of a situational one - 2-3 weeks.
Very short periods of treatment do not require the gradual withdrawal of the drug. In the case of long-term use of the drug to reduce the possibility of development of ricochet insomnia, the abolition of zolpidem should be carried out gradually (first a decrease in the daily dose and then the withdrawal of the drug). Consult your physician about the individual dosage before you decide to buy ambien online.
Alcohol enhances the sedative effect of zolpidem, joint use is not recommended. Drugs that act depressingly on the central nervous system (neuroleptics, barbiturates, other sleeping pills, anxiolytics / sedatives, antidepressants with sedative action, narcotic analgesics, antitussive central action), antiepileptic drugs, general anesthetics, antihistamines with sedative effect, antihypertensive central action; baclofen; thalidomide; pizotifen - when combined, there is an intensification of the oppressive effect on the central nervous system and the risk of respiratory depression increases; buprenorphine - risk of respiratory depression; ketoconazole (a powerful inhibitor of CYP3A4) reduces the clearance of zolpidem, in connection with which it is possible to increase its sedative effect; itraconazole (inhibitor CYP3A4) - a slight, clinically insignificant change in the pharmacokinetics and pharmacodynamics of zolpidem. Rifampicin (inducer CYP3A4) accelerates metabolism, reduces the concentration and effectiveness of zolpidem.
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