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Alcohol enhances the sedative effect of zolpidem, joint use is not recommended. Drugs that act depressingly on the central nervous system (neuroleptics, barbiturates, other sleeping pills, anxiolytics / sedatives, antidepressants with sedative action, narcotic analgesics, antitussive central action), antiepileptic drugs, general anesthetics, antihistamines with sedative effect, antihypertensive central action; baclofen; thalidomide; pizotifen - when combined, there is an intensification of the oppressive effect on the central nervous system and the risk of respiratory depression increases; buprenorphine - risk of respiratory depression; ketoconazole (a powerful inhibitor of CYP3A4) reduces the clearance of zolpidem, in connection with which it is possible to increase its sedative effect; itraconazole (inhibitor CYP3A4) - a slight, clinically insignificant change in the pharmacokinetics and pharmacodynamics of zolpidem. Rifampicin (inducer CYP3A4) accelerates metabolism, reduces the concentration and effectiveness of zolpidem.

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Doctors prescribe Ambien for insomnia. The drug helps to improve the quality of sleep, reduce period of falling asleep and a number of the night awakenings. As a rule, insomnia is associated with very stressful period in life. This is excessive fatigue at work, or stress, or other issues. To maintain a vital energy, people prefer taking a stimulant. Caffeine is one of the most popular. Coffee is not the only source of caffeine. Tea, energy drinks and other products also contain this ingredient. Therefore, consuming more caffeine products, a person is full of energy within a day. At home, many people take a pill of Ambien and hope for a good healthy sleep. And just some of them think about a compatibility of Ambien with coffee or other products containing caffeine.

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