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The initiation or abrupt withdrawal of Clonazepam in patients with epilepsy or a history of epileptic seizures may precipitate the development of seizures or an epileptic condition. Several studies have shown that about 30% of patients who received anticonvulsant therapy for three months had a decrease in drugs anticonvulsant activity. In some cases, adjusting the dose allowed to restore this activity. The risk of drug dependence increases when using high doses and with increasing duration of use and in patients with a history of drug and alcohol dependence. If it is necessary to discontinue treatment with Clonazepam, withdrawal should be made gradually by reducing the dose to reduce the risk of withdrawal syndrome. In this case, the simultaneous prescription of another antiepileptic agent is necessary. With abrupt withdrawal after long-term use or taking high doses, withdrawal syndrome occurs, characterized by agitation, fear, autonomic disturbances, insomnia, in severe cases - mental disorders.
In women planning to become pregnant, therapy with anticonvulsants should not be discontinued if the drug is used to prevent seizures because there is a high probability of epileptic status with associated hypoxia and risk to life. In individual cases, when the severity and frequency of epileptic seizures are low. It is reasonable to assume that withdrawal of therapy will not result in serious life-threatening conditions. Women should withdraw the treatment before and during pregnancy. Note that even moderately severe seizures can be harmful to the fetus. In terms of using Clonazepam for children, the risk and benefit should be evaluated because of the possibility of adverse side effects on the child's physical and mental development, including delayed. Avoid drinking alcoholic beverages during treatment with Clonazepam. Use with caution together with drugs that cause CNS depression. Concomitant use of CNS-depressant drugs or alcohol increases the likelihood of severe adverse reactions. Avoid driving a vehicle and perform work requiring quick psychomotor reactions during treatment with Clonazepam and within 3 days after its completion.
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Klonopin (Clonazepam) is a benzodiazepine derivative that has an anticonvulsant, anxiolytic, muscular-relaxing, amnestic, sedative, and hypnotic effect. It reduces the excitability of the subcortical areas of the brain (limbic system, thalamus, and hypothalamus) and disturbs their interaction with the cortex. It oppresses polysynaptic spinal reflexes. It is quickly and completely absorbed in the digestive tract. After taken orally, Cmax is achieved in 1-2 hours. It is excreted mainly in urine. 1 tablet contains 0.5 or 2 mg of Clonazepam; one blister contains 30 pcs, one pack contains 1 blister.
Increased risk of drug-related mortality from concomitant use with opioids. Suicidal thoughts or behavior (monitor). Depression. May increase or precipitate tonic-clonic seizures. Compromised respiratory function (eg, COPD, sleep apnea). Porphyria. Monitor LFTs, CBCs during long-term therapy. Assess patient's risk for abuse, misuse, addiction prior to and during therapy. Avoid abrupt cessation. Withdraw gradually. Drug or alcohol abusers. Renal impairment. Elderly. Labor & delivery. Pregnancy. Nursing mothers.
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Klonopin is one of the most prescribed drugs in the United States and also one that is commonly misused. Few drugs opioid painkillers being one are more likely to be the source of addiction for people suffering from substance use disorders. Therefore, the question of Is Klonopin addictive? is easy to answer. Klonopin is very addictive if taken in high doses or for a consistent amount of time. As the body becomes accustomed to the drug's presence and how it interacts with the brain, people become reliant on Klonopin for certain feelings, such as a relaxed state. If the person suffers from anxiety, the lack of the drug's presence could result in more severe attacks.
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